Publications in Scientific Journals

Gamblin et al. 2003:  Caspase cleavage of tauC3:  Linking amyloid and neurofibrillary tangles in Alzheimer’s disease.  Proc. Natl. Acad. Sci. U S A. 2003 Aug 19;100(17):10032-7.

Rissman et al., 2004.  Caspase-cleavage of tauC3 is an early event in Alzheimer disease tangle pathology.  J. Clin.Invest.. 2004 Jul;114(1):121-30.

De Calignon et al., 2010:  Caspase activation precedes and leads to tangles.Nature. 22;464(7292):1201-4.

Quintanilla et al., 2011:  TauC3 and Aβ cooperatively impair mitochondria in primary neurons.Neurobiol Aging. 33(3):61.

Zhao et al., 2015:  Appoptosin-Mediated Caspase Cleavage of TauC3 Contributed to Progressive Supranuclear Palsy Pathogenesis. Neuron.87(5):963-75.

Ozcelik et al., 2016:  Co-expression of truncated and full-length tau induces severe neurotoxicity.Mol. Psychiatry. 21(12): 1790–1798.

Kim et al., 2017:  Caspase-cleaved TauC3 exhibits rapid memory impairment associated with tau oligomers in a transgenic mouse model. Neurobiol. Dis. 87:19-28..

Nicholls et al., 2017:  Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.  PLoS One 22;12(5):e0177914.

Perez et al., 2017.  Caspase-Cleaved Tau Impairs Mitochondrial Dynamics in Alzheimer’s Disease. Mol.Neurobiol. 2018 Feb;55(2):1004-1018.